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Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.

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Title: Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.
Authors: Panel N; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Vo DD; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. duc.duy.vo@kemi.uu.se.; Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden. duc.duy.vo@kemi.uu.se., Hübner H; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Deluigi M; Department of Biochemistry, University of Zurich, Zürich, Switzerland., Pach S; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Bélair F; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Weikert D; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAUNeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen, Germany., Klenk C; Department of Biochemistry, University of Zurich, Zürich, Switzerland.; Rudolf Buchheim Institute of Pharmacology, Justus Liebig University, Giessen, Germany., Hilge M; Department of Biochemistry, University of Zurich, Zürich, Switzerland., Shiva N; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Brochu I; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Longpré JM; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Bällgren F; Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Saleh A; Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Hu H; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Kapla J; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Kampen S; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Cabeza de Vaca I; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Kihlberg J; Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Wettschureck N; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Centre for Molecular Medicine, Medical Faculty, Goethe University, Frankfurt am Main, Germany., Sarret P; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. philippe.sarret@usherbrooke.ca., Plückthun A; Department of Biochemistry, University of Zurich, Zürich, Switzerland. plueckthun@bioc.uzh.ch., Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. peter.gmeiner@fau.de.; FAUNeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen, Germany. peter.gmeiner@fau.de., Carlsson J; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. jens.carlsson@icm.uu.se.
Source: Nature communications [Nat Commun] 2026 Jul 22; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.
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  Data: <searchLink fieldCode="AU" term="%22Panel+N%22">Panel N</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Vo+DD%22">Vo DD</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. duc.duy.vo@kemi.uu.se.; Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden. duc.duy.vo@kemi.uu.se.<br /><searchLink fieldCode="AU" term="%22Hübner+H%22">Hübner H</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Deluigi+M%22">Deluigi M</searchLink>; Department of Biochemistry, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pach+S%22">Pach S</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Bélair+F%22">Bélair F</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Weikert+D%22">Weikert D</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAUNeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Klenk+C%22">Klenk C</searchLink>; Department of Biochemistry, University of Zurich, Zürich, Switzerland.; Rudolf Buchheim Institute of Pharmacology, Justus Liebig University, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Hilge+M%22">Hilge M</searchLink>; Department of Biochemistry, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shiva+N%22">Shiva N</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Brochu+I%22">Brochu I</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Longpré+JM%22">Longpré JM</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Bällgren+F%22">Bällgren F</searchLink>; Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Saleh+A%22">Saleh A</searchLink>; Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Kapla+J%22">Kapla J</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Kampen+S%22">Kampen S</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Cabeza+de+Vaca+I%22">Cabeza de Vaca I</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Kihlberg+J%22">Kihlberg J</searchLink>; Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Wettschureck+N%22">Wettschureck N</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Centre for Molecular Medicine, Medical Faculty, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Sarret+P%22">Sarret P</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. philippe.sarret@usherbrooke.ca.<br /><searchLink fieldCode="AU" term="%22Plückthun+A%22">Plückthun A</searchLink>; Department of Biochemistry, University of Zurich, Zürich, Switzerland. plueckthun@bioc.uzh.ch.<br /><searchLink fieldCode="AU" term="%22Gmeiner+P%22">Gmeiner P</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. peter.gmeiner@fau.de.; FAUNeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen, Germany. peter.gmeiner@fau.de.<br /><searchLink fieldCode="AU" term="%22Carlsson+J%22">Carlsson J</searchLink>; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. jens.carlsson@icm.uu.se.
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