V600E biases the BRAF kinase domain toward an activation-compatible conformational ensemble through long-range dynamic rewiring.
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| Title: | V600E biases the BRAF kinase domain toward an activation-compatible conformational ensemble through long-range dynamic rewiring. |
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| Authors: | Zhang BD; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Xi Q; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Ying YM; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Zhao DR; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Yang LQ; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Sang P; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China. |
| Source: | RSC advances [RSC Adv] 2026 Aug 11; Vol. 16 (40), pp. 46674-46689. Date of Electronic Publication: 2026 Aug 11 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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